复方中药网络药理学方法研究进展Research Progress of Network Pharmacology Method of Compound Traditional Chinese Medicine
张华敏;刘思鸿;高宏杰;贡磊磊;
摘要(Abstract):
复方中药是辨证审因决定治法,选择合适的药物药量,按照组成原则妥善配伍而成的一组药物。现代药理研究结果表明,复方中药具有"多成分、多靶点和多途径"协同作用的特点,使其研究更加难以展开。随着医学科学和生命科学步入后基因组时代,以系统生物学、多项药理学生物信息学相结合的网络药理学被广泛应用于复方中药的现代化研究。网络药理学强调网络靶标的研究模式,从整体上探索药物与疾病的相关性,这与复方中药的整体性和系统性不谋而合。本文将就网络药理学在复方中药中的研究方法、应用和存在的问题进行概述,以期为复方中药的网络药理学研究提供参考。
关键词(KeyWords): 复方中药;网络药理学;研究进展
基金项目(Foundation): 国家自然基金面上项目(No.81873199)
作者(Authors): 张华敏;刘思鸿;高宏杰;贡磊磊;
DOI: 10.14009/j.issn.1672-2124.2019.10.035
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